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Interstrand cross-linking implies contrasting structural consequences for DNA: insights from molecular dynamics
Oxidatively-generated interstrand cross-links rank among the most deleterious DNA lesions. They originate from abasic sites, whose aldehyde group can form a covalent adduct after condensation with the exocyclic amino group of purines, sometimes with remarkably high yields. We use explicit solvent mo...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5389527/ https://ncbi.nlm.nih.gov/pubmed/27986856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1253 |
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