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Prion protein dynamics before aggregation

Prion diseases, like Alzheimer’s disease and Parkinson disease, are rapidly progressive neurodegenerative disorders caused by misfolding followed by aggregation and accumulation of protein deposits in neuronal cells. Here we measure intramolecular polypeptide backbone reconfiguration as a way to und...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Srivastava, Kinshuk Raj, Lapidus, Lisa J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389334/
https://ncbi.nlm.nih.gov/pubmed/28320943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620400114
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