Data-based modeling of drug penetration relates human skin barrier function to the interplay of diffusivity and free-energy profiles

Based on experimental concentration depth profiles of the antiinflammatory drug dexamethasone in human skin, we model the time-dependent drug penetration by the 1D general diffusion equation that accounts for spatial variations in the diffusivity and free energy. For this, we numerically invert the...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Schulz, Robert, Yamamoto, Kenji, Klossek, André, Flesch, Roman, Hönzke, Stefan, Rancan, Fiorenza, Vogt, Annika, Blume-Peytavi, Ulrike, Hedtrich, Sarah, Schäfer-Korting, Monika, Rühl, Eckart, Netz, Roland R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2017
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389326/
https://ncbi.nlm.nih.gov/pubmed/28320932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620636114
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