Serine-to-Asparagine Substitution in the GyrA Gene Leads to Quinolone Resistance in Moxifloxacin-Exposed Chlamydia pneumoniae

Quinolone resistance of Chlamydia pneumoniae has not been described previously. Serial subcultures of C. pneumoniae under increasing moxifloxacin concentrations (0.0125 to 6.4 mg/liter) resulted in a 256-fold MIC increase compared to moxifloxacin-naive strains. GyrA gene sequencing revealed a novel...

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Detaylı Bibliyografya
Asıl Yazarlar: Rupp, Jan, Gebert, Andreas, Solbach, Werner, Maass, Matthias
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2005
Konular:
Mechanisms of Resistance
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC538918/
https://ncbi.nlm.nih.gov/pubmed/15616321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.1.406-407.2005
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