Palmitate Increases β-site AβPP-Cleavage Enzyme 1 Activity and Amyloid-β Genesis by Evoking Endoplasmic Reticulum Stress and Subsequent C/EBP Homologous Protein Activation

Epidemiological studies implicate diets rich in saturated free fatty acids (sFFA) as a potential risk factor for developing Alzheimer’s disease (AD). In particular, high plasma levels of the sFFA palmitic acid (palmitate) were shown to inversely correlate with cognitive function. However, the cellul...

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Bibliographic Details
Published in:J Alzheimers Dis
Main Authors: Marwarha, Gurdeep, Rostad, Stephen, Lilek, Jaclyn, Kleinjan, Mason, Schommer, Jared, Ghribi, Othman
Format: Artigo
Language:Inglês
Published: IOS Press 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389045/
https://ncbi.nlm.nih.gov/pubmed/28304295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-161130
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