Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice

Apart from its potent antioxidant property, recent studies have revealed that melatonin promotes PI3K/Akt phosphorylation following focal cerebral ischemia (FCI) in mice. However, it is not clear (i) whether increased PI3K/Akt phosphorylation is a concomitant event or it directly contributes to mela...

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Udgivet i:Redox Biol
Main Authors: Kilic, Ulkan, Caglayan, Ahmet Burak, Beker, Mustafa Caglar, Gunal, Mehmet Yalcin, Caglayan, Berrak, Yalcin, Esra, Kelestemur, Taha, Gundogdu, Reyhan Zeynep, Yulug, Burak, Yılmaz, Bayram, Kerman, Bilal Ersen, Kilic, Ertugrul
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388917/
https://ncbi.nlm.nih.gov/pubmed/28395173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.04.006
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