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Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions
Base editing is a recently developed approach to genome editing that uses a fusion protein containing a catalytically defective Streptococcus pyogenes Cas9, a cytidine deaminase, and an inhibitor of base excision repair to induce programmable, single-nucleotide changes in the DNA of living cells wit...
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| Publicat a: | Nat Biotechnol |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5388574/ https://ncbi.nlm.nih.gov/pubmed/28191901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3803 |
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