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Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E(2) and D(2) by activated human leukocytes
The 2 hemiketal (HK) eicosanoids HKD(2) and HKE(2) are the major products of the biosynthetic crossover of the 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) pathways. HKs result from the rearrangement of a di-endoperoxide intermediate formed in the COX-2-dependent oxygenation of 5S-hydroxyeico...
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| Veröffentlicht in: | FASEB J |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Federation of American Societies for Experimental Biology
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5388546/ https://ncbi.nlm.nih.gov/pubmed/28096231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601136R |
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