Optical control of pain in vivo with a photoactive mGlu(5) receptor negative allosteric modulator

Light-operated drugs constitute a major target in drug discovery, since they may provide spatiotemporal resolution for the treatment of complex diseases (i.e. chronic pain). JF-NP-26 is an inactive photocaged derivative of the metabotropic glutamate type 5 (mGlu(5)) receptor negative allosteric modu...

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Bibliographic Details
Published in:eLife
Main Authors: Font, Joan, López-Cano, Marc, Notartomaso, Serena, Scarselli, Pamela, Di Pietro, Paola, Bresolí-Obach, Roger, Battaglia, Giuseppe, Malhaire, Fanny, Rovira, Xavier, Catena, Juanlo, Giraldo, Jesús, Pin, Jean-Philippe, Fernández-Dueñas, Víctor, Goudet, Cyril, Nonell, Santi, Nicoletti, Ferdinando, Llebaria, Amadeu, Ciruela, Francisco
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2017
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388536/
https://ncbi.nlm.nih.gov/pubmed/28395733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23545
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