Total biosynthesis of the cyclic AMP booster forskolin from Coleus forskohlii

Forskolin is a unique structurally complex labdane-type diterpenoid used in the treatment of glaucoma and heart failure based on its activity as a cyclic AMP booster. Commercial production of forskolin relies exclusively on extraction from its only known natural source, the plant Coleus forskohlii,...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Pateraki, Irini, Andersen-Ranberg, Johan, Jensen, Niels Bjerg, Wubshet, Sileshi Gizachew, Heskes, Allison Maree, Forman, Victor, Hallström, Björn, Hamberger, Britta, Motawia, Mohammed Saddik, Olsen, Carl Erik, Staerk, Dan, Hansen, Jørgen, Møller, Birger Lindberg, Hamberger, Björn
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388535/
https://ncbi.nlm.nih.gov/pubmed/28290983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23001
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