Oxidation and cyclization of casbene in the biosynthesis of Euphorbia factors from mature seeds of Euphorbia lathyris L.

The seed oil of Euphorbia lathyris L. contains a series of macrocyclic diterpenoids known as Euphorbia factors. They are the current industrial source of ingenol mebutate, which is approved for the treatment of actinic keratosis, a precancerous skin condition. Here, we report an alcohol dehydrogenas...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Luo, Dan, Callari, Roberta, Hamberger, Britta, Wubshet, Sileshi Gizachew, Nielsen, Morten T., Andersen-Ranberg, Johan, Hallström, Björn M., Cozzi, Federico, Heider, Harald, Lindberg Møller, Birger, Staerk, Dan, Hamberger, Björn
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003294/
https://ncbi.nlm.nih.gov/pubmed/27506796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607504113
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