Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability

The rules of engagement between zinc finger transcription factors and DNA have been partly defined by in vitro DNA-binding and structural studies, but less is known about how these rules apply in vivo. Here, we demonstrate how a missense mutation in the second zinc finger of Krüppel-like factor-1 (K...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nucleic Acids Res
मुख्य लेखकों: Gillinder, Kevin R., Ilsley, Melissa D., Nébor, Danitza, Sachidanandam, Ravi, Lajoie, Mathieu, Magor, Graham W., Tallack, Michael R., Bailey, Timothy, Landsberg, Michael J., Mackay, Joel P., Parker, Michael W., Miles, Luke A., Graber, Joel H., Peters, Luanne L., Bieker, James J., Perkins, Andrew C.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2017
विषय:
Gene regulation, Chromatin and Epigenetics
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388391/
https://ncbi.nlm.nih.gov/pubmed/28180284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1014
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