Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development

Transcription factor control of cell-specific downstream targets can be significantly altered when the controlling factor is mutated. We show that the semi-dominant neonatal anemia (Nan) mutation in the EKLF/KLF1 transcription factor leads to ectopic expression of proteins that are not normally expr...

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Enregistré dans:
Détails bibliographiques
Publié dans:Development
Auteurs principaux: Planutis, Antanas, Xue, Li, Trainor, Cecelia D., Dangeti, Mohan, Gillinder, Kevin, Siatecka, Miroslawa, Nebor, Danitza, Peters, Luanne L., Perkins, Andrew C., Bieker, James J.
Format: Artigo
Langue:Inglês
Publié: The Company of Biologists Ltd 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341802/
https://ncbi.nlm.nih.gov/pubmed/28143845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.145656
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