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Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development
Transcription factor control of cell-specific downstream targets can be significantly altered when the controlling factor is mutated. We show that the semi-dominant neonatal anemia (Nan) mutation in the EKLF/KLF1 transcription factor leads to ectopic expression of proteins that are not normally expr...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Development |
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| Κύριοι συγγραφείς: | , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
The Company of Biologists Ltd
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5341802/ https://ncbi.nlm.nih.gov/pubmed/28143845 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.145656 |
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