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Drain the lysosome: Development of the novel orally available autophagy inhibitor ROC-325
Although macroautophagy/autophagy is a key contributor to malignant pathogenesis and therapeutic resistance, there are few FDA-approved agents that significantly affect this pathway. We used medicinal chemistry strategies to develop ROC-325, an orally available novel inhibitor of lysosomal-mediated...
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| Udgivet i: | Autophagy |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5388230/ https://ncbi.nlm.nih.gov/pubmed/28118053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1280222 |
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