Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice

Whether obesity accelerates or suppresses autophagy in adipose tissue is still debatable. To clarify dysregulation of autophagy and its role in pathologies of obese adipose tissue, we focused on lysosomal function, protease maturation and activity, both in vivo and in vitro. First, we showed that au...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Mizunoe, Yuhei, Sudo, Yuka, Okita, Naoyuki, Hiraoka, Hidenori, Mikami, Kentaro, Narahara, Tomohiro, Negishi, Arisa, Yoshida, Miki, Higashibata, Rikako, Watanabe, Shukoh, Kaneko, Hiroki, Natori, Daiki, Furuichi, Takuma, Yasukawa, Hiromine, Kobayashi, Masaki, Higami, Yoshikazu
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Basic Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388215/
https://ncbi.nlm.nih.gov/pubmed/28121218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1274850
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