Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice

Whether obesity accelerates or suppresses autophagy in adipose tissue is still debatable. To clarify dysregulation of autophagy and its role in pathologies of obese adipose tissue, we focused on lysosomal function, protease maturation and activity, both in vivo and in vitro. First, we showed that au...

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Bibliographic Details
Published in:Autophagy
Main Authors: Mizunoe, Yuhei, Sudo, Yuka, Okita, Naoyuki, Hiraoka, Hidenori, Mikami, Kentaro, Narahara, Tomohiro, Negishi, Arisa, Yoshida, Miki, Higashibata, Rikako, Watanabe, Shukoh, Kaneko, Hiroki, Natori, Daiki, Furuichi, Takuma, Yasukawa, Hiromine, Kobayashi, Masaki, Higami, Yoshikazu
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2017
Subjects:
Basic Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388215/
https://ncbi.nlm.nih.gov/pubmed/28121218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1274850
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