Targeted Deletion of mek5 Causes Early Embryonic Death and Defects in the Extracellular Signal-Regulated Kinase 5/Myocyte Enhancer Factor 2 Cell Survival Pathway

To elucidate the physiological significance of MEK5 in vivo, we have examined the effect of mek5 gene elimination in mice. Heterozygous mice appear to be healthy and were fertile. However, mek5(−)(/)(−) embryos die at approximately embryonic day 10.5 (E10.5). The phenotype of the mek5(−)(/)(−) embry...

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Detalhes bibliográficos
Main Authors: Wang, Xin, Merritt, Anita J., Seyfried, Jan, Guo, Chun, Papadakis, Emmanouil S., Finegan, Katherine G., Kayahara, Midori, Dixon, Jill, Boot-Handford, Raymond P., Cartwright, Elizabeth J., Mayer, Ulrike, Tournier, Cathy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC538774/
https://ncbi.nlm.nih.gov/pubmed/15601854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.1.336-345.2005
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