Microvascular patterning is controlled by fine-tuning the Akt signal

We investigated the functions of Akt during vascular development and remodeling by using an inducible endothelial cell-specific driver of the dominant-active myrAkt. We found that sustained signaling in response to overexpression of myrAkt led to embryonic lethality, edema, and vascular malformation...

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Autori principali: Sun, Jing Fang, Phung, Thuy, Shiojima, Ichiro, Felske, Terri, Upalakalin, J. Nalinee, Feng, Dian, Kornaga, Tad, Dor, Talia, Dvorak, Ann M., Walsh, Kenneth, Benjamin, Laura E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC538747/
https://ncbi.nlm.nih.gov/pubmed/15611473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403198102
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