Functional and structural studies on the Neisseria gonorrhoeae GmhA, the first enzyme in the glycero‐manno‐heptose biosynthesis pathways, demonstrate a critical role in lipooligosaccharide synthesis and gonococcal viability

Sedoheptulose‐7‐phosphate isomerase, GmhA, is the first enzyme in the biosynthesis of nucleotide‐activated‐glycero‐manno‐heptoses and an attractive, yet underexploited, target for development of broad‐spectrum antibiotics. We demonstrated that GmhA homologs in Neisseria gonorrhoeae and N. meningitid...

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Bibliografische gegevens
Gepubliceerd in:Microbiologyopen
Hoofdauteurs: Wierzbicki, Igor H., Zielke, Ryszard A., Korotkov, Konstantin V., Sikora, Aleksandra E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2017
Onderwerpen:
Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5387315/
https://ncbi.nlm.nih.gov/pubmed/28063198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mbo3.432
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