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Functional and structural studies on the Neisseria gonorrhoeae GmhA, the first enzyme in the glycero‐manno‐heptose biosynthesis pathways, demonstrate a critical role in lipooligosaccharide synthesis and gonococcal viability
Sedoheptulose‐7‐phosphate isomerase, GmhA, is the first enzyme in the biosynthesis of nucleotide‐activated‐glycero‐manno‐heptoses and an attractive, yet underexploited, target for development of broad‐spectrum antibiotics. We demonstrated that GmhA homologs in Neisseria gonorrhoeae and N. meningitid...
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| Vydáno v: | Microbiologyopen |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
John Wiley and Sons Inc.
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5387315/ https://ncbi.nlm.nih.gov/pubmed/28063198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mbo3.432 |
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