Functional and structural studies on the Neisseria gonorrhoeae GmhA, the first enzyme in the glycero‐manno‐heptose biosynthesis pathways, demonstrate a critical role in lipooligosaccharide synthesis and gonococcal viability

Sedoheptulose‐7‐phosphate isomerase, GmhA, is the first enzyme in the biosynthesis of nucleotide‐activated‐glycero‐manno‐heptoses and an attractive, yet underexploited, target for development of broad‐spectrum antibiotics. We demonstrated that GmhA homologs in Neisseria gonorrhoeae and N. meningitid...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Microbiologyopen
Päätekijät: Wierzbicki, Igor H., Zielke, Ryszard A., Korotkov, Konstantin V., Sikora, Aleksandra E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2017
Aiheet:
Original Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5387315/
https://ncbi.nlm.nih.gov/pubmed/28063198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mbo3.432
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