Effects of Febrile Temperature on Adenoviral Infection and Replication: Implications for Viral Therapy of Cancer

We previously conducted a phase I/II study using arterial infusions of ONYX-015 (dl1520), a replication-selective adenoviral vector, with E1b deleted, for patients with metastatic colorectal cancer. No dose-limiting toxicities occurred, but >90% of the patients experienced fever. The effects of t...

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Detalhes bibliográficos
Main Authors: Thorne, Stephen H., Brooks, Gabriel, Lee, Yeun-Ling, Au, Tina, Eng, Lawrence F., Reid, Tony
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC538681/
https://ncbi.nlm.nih.gov/pubmed/15596850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.1.581-591.2005
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