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Effects of Febrile Temperature on Adenoviral Infection and Replication: Implications for Viral Therapy of Cancer
We previously conducted a phase I/II study using arterial infusions of ONYX-015 (dl1520), a replication-selective adenoviral vector, with E1b deleted, for patients with metastatic colorectal cancer. No dose-limiting toxicities occurred, but >90% of the patients experienced fever. The effects of t...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC538681/ https://ncbi.nlm.nih.gov/pubmed/15596850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.1.581-591.2005 |
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