Rv2299c, a novel dendritic cell-activating antigen of Mycobacterium tuberculosis, fused-ESAT-6 subunit vaccine confers improved and durable protection against the hypervirulent strain HN878 in mice

Understanding functional interactions between DCs and antigens is necessary for achieving an optimal and desired immune response during vaccine development. Here, we identified and characterized protein Rv2299c (heat-shock protein 90 family), which effectively induced DC maturation. The Rv2299c-matu...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Choi, Han-Gyu, Choi, Seunga, Back, Yong Woo, Paik, Seungwha, Park, Hye-Soo, Kim, Woo Sik, Kim, Hongmin, Cha, Seung Bin, Choi, Chul Hee, Shin, Sung Jae, Kim, Hwa-Jung
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386736/
https://ncbi.nlm.nih.gov/pubmed/28193909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15256
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