Identification of evolutionarily conserved DNA damage response genes that alter sensitivity to cisplatin

Ovarian, head and neck, and other cancers are commonly treated with cisplatin and other DNA damaging cytotoxic agents. Altered DNA damage response (DDR) contributes to resistance of these tumors to chemotherapies, some targeted therapies, and radiation. DDR involves multiple protein complexes and si...

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Publicado en:Oncotarget
Autores principales: Gaponova, Anna V., Deneka, Alexander Y., Beck, Tim N., Liu, Hanqing, Andrianov, Gregory, Nikonova, Anna S., Nicolas, Emmanuelle, Einarson, Margret B., Golemis, Erica A., Serebriiskii, Ilya G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386675/
https://ncbi.nlm.nih.gov/pubmed/27863405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13353
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