Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation

Bisphosphonates are diphosphate analogs that inhibit the intermediate enzymes of the mevalonate pathway. Here, we compared the effects of a farnesyl diphosphate synthase inhibitor, zoledronate, and a geranylgeranyl diphosphate synthase (GGDPS) inhibitor, digeranyl bisphosphonate (DGBP), on lymphocyt...

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Foilsithe in:Cell Death Dis
Main Authors: Agabiti, Sherry S, Li, Jin, Wiemer, Andrew J
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2017
Ábhair:
Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386513/
https://ncbi.nlm.nih.gov/pubmed/28300835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.101
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