RASAL2, a RAS GTPase-activating protein, inhibits stemness and epithelial–mesenchymal transition via MAPK/SOX2 pathway in bladder cancer

Muscle-invasive or metastatic bladder cancer (BCa) is associated with a very poor prognosis, and the underlying mechanism remains poorly understood. In this study, we demonstrate RASAL2, a RAS GTPase-activating protein (RAS GAP), acts as a tumor suppressor in BCa. First, RASAL2 was downregulated in...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cell Death Dis
Hauptverfasser: Hui, Ke, Gao, Yang, Huang, Jun, Xu, Shan, Wang, Bin, Zeng, Jin, Fan, Jinhai, Wang, Xinyang, Yue, Yangyang, Wu, Shiqi, Hsieh, Jer-Tsong, He, Dalin, Wu, Kaijie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
Schlagworte:
Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386500/
https://ncbi.nlm.nih.gov/pubmed/28182001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.9
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge