RASAL2, a RAS GTPase-activating protein, inhibits stemness and epithelial–mesenchymal transition via MAPK/SOX2 pathway in bladder cancer

Muscle-invasive or metastatic bladder cancer (BCa) is associated with a very poor prognosis, and the underlying mechanism remains poorly understood. In this study, we demonstrate RASAL2, a RAS GTPase-activating protein (RAS GAP), acts as a tumor suppressor in BCa. First, RASAL2 was downregulated in...

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Vydáno v:Cell Death Dis
Hlavní autoři: Hui, Ke, Gao, Yang, Huang, Jun, Xu, Shan, Wang, Bin, Zeng, Jin, Fan, Jinhai, Wang, Xinyang, Yue, Yangyang, Wu, Shiqi, Hsieh, Jer-Tsong, He, Dalin, Wu, Kaijie
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386500/
https://ncbi.nlm.nih.gov/pubmed/28182001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.9
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