RASAL2, a RAS GTPase-activating protein, inhibits stemness and epithelial–mesenchymal transition via MAPK/SOX2 pathway in bladder cancer

Muscle-invasive or metastatic bladder cancer (BCa) is associated with a very poor prognosis, and the underlying mechanism remains poorly understood. In this study, we demonstrate RASAL2, a RAS GTPase-activating protein (RAS GAP), acts as a tumor suppressor in BCa. First, RASAL2 was downregulated in...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Dis
Egile Nagusiak: Hui, Ke, Gao, Yang, Huang, Jun, Xu, Shan, Wang, Bin, Zeng, Jin, Fan, Jinhai, Wang, Xinyang, Yue, Yangyang, Wu, Shiqi, Hsieh, Jer-Tsong, He, Dalin, Wu, Kaijie
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2017
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386500/
https://ncbi.nlm.nih.gov/pubmed/28182001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.9
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