Targeted gene disruption of the endogenous c-abl locus by homologous recombination with DNA encoding a selectable fusion protein.

We have introduced a substitution mutation into the c-abl locus of murine embryonic stem cells by homologous recombination between exogenously added DNA and the endogenous gene. Model constructs were initially generated that consisted of a promoterless selectable neomycin resistance marker inserted...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Schwartzberg, P L, Robertson, E J, Goff, S P
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1990
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53865/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2183226/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.8.3210
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