Targeted gene disruption of the endogenous c-abl locus by homologous recombination with DNA encoding a selectable fusion protein.

We have introduced a substitution mutation into the c-abl locus of murine embryonic stem cells by homologous recombination between exogenously added DNA and the endogenous gene. Model constructs were initially generated that consisted of a promoterless selectable neomycin resistance marker inserted...

Fuld beskrivelse

Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Schwartzberg, P L, Robertson, E J, Goff, S P
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1990
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53865/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2183226/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.8.3210
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!