Targeted gene disruption of the endogenous c-abl locus by homologous recombination with DNA encoding a selectable fusion protein.

We have introduced a substitution mutation into the c-abl locus of murine embryonic stem cells by homologous recombination between exogenously added DNA and the endogenous gene. Model constructs were initially generated that consisted of a promoterless selectable neomycin resistance marker inserted...

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Sonraí Bibleagrafaíochta
Main Authors: Schwartzberg, P L, Robertson, E J, Goff, S P
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1990
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC53865/
https://ncbi.nlm.nih.gov/pubmed/2183226
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