Dicer promotes tumorigenesis by translocating to nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells

Dicer, a member of the RNase III family of endoribonucleases, has an important role in regulating methylation of CpG islands in mammal cancer cells. However, the underlying mechanism of action remains unclear. In this study, we demonstrated that upregulation of Dicer in cholangiocarcinoma (CCA) cell...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Cheng, Wenlong, Qi, Yongqiang, Tian, Li, Wang, Bing, Huang, Wenhua, Chen, Yongjun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386496/
https://ncbi.nlm.nih.gov/pubmed/28230864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.57
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