Loss of BRG1 induces CRC cell senescence by regulating p53/p21 pathway

Brahma-related gene-1 (BRG1) is the specific ATPase of switch/sucrose nonfermentable chromatin-remodeling complex that is aberrantly expressed or mutated in various cancers. However, the exact role of BRG1 in oncogenesis remains unknown. In this study, we demonstrate that the knockdown (KD) of BRG1...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Wang, Guihua, Fu, Yinjia, Hu, Fuqing, Lan, Jinqing, Xu, Feng, Yang, Xi, Luo, Xuelai, Wang, Jing, Hu, Junbo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386468/
https://ncbi.nlm.nih.gov/pubmed/28182012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.1
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