IL-17-mediated mitochondrial dysfunction impairs apoptosis in rheumatoid arthritis synovial fibroblasts through activation of autophagy

Fibroblast-like synoviocytes (FLSs) are a major cell population of the pannus that invades cartilage and bone in rheumatoid arthritis (RA). FLS resistance to apoptosis is a major characteristic of RA. The aims of this study were to investigate the effects of interleukin-17 (IL-17) and IL-17-producin...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Kim, Eun Kyung, Kwon, Jeong-Eun, Lee, Seon-Young, Lee, Eun-Jung, Kim, Da Som, Moon, Su-Jin, Lee, Jennifer, Kwok, Seung-Ki, Park, Sung-Hwan, Cho, Mi-La
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386390/
https://ncbi.nlm.nih.gov/pubmed/28102843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.490
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