A drug screen using human iPSC-derived hepatocyte-like cells identifies cardiac glycosides as a potential treatment for hypercholesterolemia

Efforts to identify pharmaceuticals to treat heritable metabolic liver diseases have been hampered by the lack of models. However, cells with hepatocyte characteristics can be produced from induced pluripotent stem cells (iPSCs). Here we have used hepatocyte–like cells generated from homozygous fami...

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Veröffentlicht in:Cell Stem Cell
Hauptverfasser: Cayo, Max A., Mallanna, Sunil K., Di Furio, Francesca, Jing, Ran, Tolliver, Lauren B., Bures, Matthew, Urick, Amanda, Noto, Fallon K., Pashos, Evanthia E., Greseth, Matthew D., Czarnecki, Maciej, Traktman, Paula, Yang, Wenli, Morrisey, Edward E., Grompe, Markus, Rader, Daniel J., Duncan, Stephen A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385853/
https://ncbi.nlm.nih.gov/pubmed/28388428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.01.011
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