Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor

T-cell receptor-CD3 complex (TCR) is a versatile signaling machine that can initiate antigen-specific immune responses based on various biochemical changes of CD3 cytoplasmic domains, but the underlying structural basis remains elusive. Here we developed biophysical approaches to study the conformat...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Guo, Xingdong, Yan, Chengsong, Li, Hua, Huang, Wenmao, Shi, Xiaoshan, Huang, Min, Wang, Yingfang, Pan, Weiling, Cai, Mingjun, Li, Lunyi, Wu, Wei, Bai, Yibing, Zhang, Chi, Liu, Zhijun, Wang, Xinyan, Zhang, Xiaohui F, Tang, Chun, Wang, Hongda, Liu, Wanli, Ouyang, Bo, Wong, Catherine C, Cao, Yi, Xu, Chenqi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385618/
https://ncbi.nlm.nih.gov/pubmed/28337984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.42
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