Engineered Split-TET2 Enzyme for Inducible Epigenetic Remodeling

[Image: see text] The Ten-eleven translocation (TET) family of 5-methylcytosine (5mC) dioxygenases catalyze the conversion of 5mC into 5-hydroxymethylcytosine (5hmC) and further oxidized species to promote active DNA demethylation. Here we engineered a split-TET2 enzyme to enable temporal control of...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Lee, Minjung, Li, Jia, Liang, Yi, Ma, Guolin, Zhang, Jixiang, He, Lian, Liu, Yuliang, Li, Qian, Li, Minyong, Sun, Deqiang, Zhou, Yubin, Huang, Yun
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385525/
https://ncbi.nlm.nih.gov/pubmed/28294608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b01459
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados