Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity

D-aspartate levels in the brain are regulated by the catabolic enzyme D-aspartate oxidase (DDO). D-aspartate activates NMDA receptors, and influences brain connectivity and behaviors relevant to schizophrenia in animal models. In addition, recent evidence reported a significant reduction of D-aspart...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sacchi, Silvia, Novellis, Vito De, Paolone, Giovanna, Nuzzo, Tommaso, Iannotta, Monica, Belardo, Carmela, Squillace, Marta, Bolognesi, Paolo, Rosini, Elena, Motta, Zoraide, Frassineti, Martina, Bertolino, Alessandro, Pollegioni, Loredano, Morari, Michele, Maione, Sabatino, Errico, Francesco, Usiello, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385520/
https://ncbi.nlm.nih.gov/pubmed/28393897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46288
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