Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity

D-aspartate levels in the brain are regulated by the catabolic enzyme D-aspartate oxidase (DDO). D-aspartate activates NMDA receptors, and influences brain connectivity and behaviors relevant to schizophrenia in animal models. In addition, recent evidence reported a significant reduction of D-aspart...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Sacchi, Silvia, Novellis, Vito De, Paolone, Giovanna, Nuzzo, Tommaso, Iannotta, Monica, Belardo, Carmela, Squillace, Marta, Bolognesi, Paolo, Rosini, Elena, Motta, Zoraide, Frassineti, Martina, Bertolino, Alessandro, Pollegioni, Loredano, Morari, Michele, Maione, Sabatino, Errico, Francesco, Usiello, Alessandro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385520/
https://ncbi.nlm.nih.gov/pubmed/28393897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46288
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