Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity

D-aspartate levels in the brain are regulated by the catabolic enzyme D-aspartate oxidase (DDO). D-aspartate activates NMDA receptors, and influences brain connectivity and behaviors relevant to schizophrenia in animal models. In addition, recent evidence reported a significant reduction of D-aspart...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Sacchi, Silvia, Novellis, Vito De, Paolone, Giovanna, Nuzzo, Tommaso, Iannotta, Monica, Belardo, Carmela, Squillace, Marta, Bolognesi, Paolo, Rosini, Elena, Motta, Zoraide, Frassineti, Martina, Bertolino, Alessandro, Pollegioni, Loredano, Morari, Michele, Maione, Sabatino, Errico, Francesco, Usiello, Alessandro
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385520/
https://ncbi.nlm.nih.gov/pubmed/28393897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46288
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