Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice

AIM: To clarify the roles of TWEAK and its receptor Fn14 in 5-fluorouracil (5-FU)-induced diarrhea. METHODS: Diarrhea was induced in wild-type (WT), Fn14 knockout (KO), and IL-13 receptor (IL-13R)α1 KO BALB/c mice using a single injection of 5-FU. Histological analysis, cytokine analysis, and flow c...

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Detalhes bibliográficos
Publicado no:World J Gastroenterol
Main Authors: Sezaki, Takuhito, Hirata, Yuki, Hagiwara, Teruki, Kawamura, Yuki I, Okamura, Tadashi, Takanashi, Rieko, Nakano, Kenta, Tamura-Nakano, Miwa, Burkly, Linda C, Dohi, Taeko
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2017
Assuntos:
Basic Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385396/
https://ncbi.nlm.nih.gov/pubmed/28428709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v23.i13.2294
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