Directed Evolution of Retrovirus Envelope Protein Cytoplasmic Tails Guided by Functional Incorporation into Lentivirus Particles

In contrast to most gammaretrovirus envelope proteins (Env), the Gibbon ape leukemia virus (GaLV) Env protein does not mediate the infectivity of human immunodeficiency virus type 1 (HIV-1) particles. We made use of this observation to set up a directed evolution system by creating a library of GaLV...

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Detalhes bibliográficos
Main Authors: Merten, Christoph A., Stitz, Jörn, Braun, Gundula, Poeschla, Eric M., Cichutek, Klaus, Buchholz, Christian J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC538528/
https://ncbi.nlm.nih.gov/pubmed/15613311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.2.834-840.2005
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