Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer's Disease

Synaptic loss is the structural basis for memory impairment in Alzheimer's disease (AD). While the underlying pathological mechanism remains elusive, it is known that misfolded proteins accumulate as β-amyloid (Aβ) plaques and hyperphosphorylated Tau tangles decades before the onset of clinical...

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Bibliografiske detaljer
Udgivet i:Neural Plast
Main Authors: Xu, Lingyan, Ren, Zhiyun, Chow, Frances E., Tsai, Richard, Liu, Tongzheng, Rizzolio, Flavio, Boffo, Silvia, Xu, Yungen, Huang, Shaohui, Lippa, Carol F., Gong, Yuesong
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi 2017
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385220/
https://ncbi.nlm.nih.gov/pubmed/28458925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/3270725
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