Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer's Disease

Synaptic loss is the structural basis for memory impairment in Alzheimer's disease (AD). While the underlying pathological mechanism remains elusive, it is known that misfolded proteins accumulate as β-amyloid (Aβ) plaques and hyperphosphorylated Tau tangles decades before the onset of clinical...

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Detalhes bibliográficos
Publicado no:Neural Plast
Main Authors: Xu, Lingyan, Ren, Zhiyun, Chow, Frances E., Tsai, Richard, Liu, Tongzheng, Rizzolio, Flavio, Boffo, Silvia, Xu, Yungen, Huang, Shaohui, Lippa, Carol F., Gong, Yuesong
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385220/
https://ncbi.nlm.nih.gov/pubmed/28458925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/3270725
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