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Cryo-EM structure of a separase-securin complex at near-atomic resolution

Separase is a caspase-family protease that initiates chromatid segregation by cleaving the kleisin subunits (Scc1 and Rec8) of cohesin, and regulates centrosome duplication and mitotic spindle function through cleavage of kendrin and Slk19. To understand the mechanisms of separase regulation by secu...

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Dades bibliogràfiques
Publicat a:Nat Struct Mol Biol
Autors principals: Boland, Andreas, Martin, Thomas G., Zhang, Ziguo, Yang, Jing, Bai, Xiao-chen, Chang, Leifu, Scheres, Sjors H.W., Barford, David
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385133/
https://ncbi.nlm.nih.gov/pubmed/28263324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3386
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