A neuronal MCT2 knockdown in the rat somatosensory cortex reduces both the NMR lactate signal and the BOLD response during whisker stimulation

Although several in vitro and ex vivo evidence support the existence of lactate exchange between astrocytes and neurons, a direct demonstration in vivo is still lacking. In the present study, a lentiviral vector carrying a short hairpin RNA (shRNA) was used to downregulate the expression of the mono...

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Udgivet i:PLoS One
Main Authors: Mazuel, Leslie, Blanc, Jordy, Repond, Cendrine, Bouchaud, Véronique, Raffard, Gérard, Déglon, Nicole, Bonvento, Gilles, Pellerin, Luc, Bouzier-Sore, Anne-Karine
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384673/
https://ncbi.nlm.nih.gov/pubmed/28388627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174990
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