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A fluorescent reporter mouse for inflammasome assembly demonstrates an important role for cell bound and free ASC specks during in vivo infection

Inflammasome activation is associated with numerous diseases. However, in vivo detection of the activated inflammasome complex has been limited by a dearth of tools. We developed transgenic mice that ectopically express the fluorescent adaptor protein, ASC (apoptosis-associated speck-like protein co...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Tzeng, Te-Chen Jenny, Schattgen, Stefan, Monks, Brian, Wang, Donghai, Cerny, Anna, Latz, Eicke, Fitzgerald, Katherine, Golenbock, Douglas T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384574/
https://ncbi.nlm.nih.gov/pubmed/27346360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.06.011
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