Evaluation of permeability, doxorubicin delivery, and drug retention in a rat brain tumor model after ultrasound-induced blood-tumor barrier disruption

Drug delivery in brain tumors is challenging because of the presence of blood-brain barrier (BBB) and the blood-tumor barrier (BTB). Focused ultrasound (FUS) combined with microbubbles can enhance the permeability of the BTB in brain tumors, as well as disrupting the BBB in the surrounding tissue. I...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Park, Juyoung, Aryal, Muna, Vykhodtseva, Natalia, Zhang, Yong-Zhi, McDannold, Nathan
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384106/
https://ncbi.nlm.nih.gov/pubmed/27742444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2016.10.011
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