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dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective
Neurons rely on mitochondria as their preferred source of energy. Mutations in PINK1 and PARKIN cause neuronal death in early-onset Parkinson's disease (PD), thought to be due to mitochondrial dysfunction. In Drosophila pink1 and parkin mutants, mitochondrial defects lead to the compensatory up...
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| 發表在: | Cell Death Differ |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5384021/ https://ncbi.nlm.nih.gov/pubmed/28211874 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.158 |
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