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Human Pot1 OB-fold mutations unleash rampant telomere instability to initiate tumorigenesis
Chromosomal aberrations are a hallmark of human cancers, with complex cytogenetic rearrangements leading to genetic changes permissive for cancer initiation and progression. Protection of Telomere 1 (POT1) is an essential component of the shelterin complex and functions to maintain chromosome stabil...
Kaydedildi:
| Yayımlandı: | Oncogene |
|---|---|
| Asıl Yazarlar: | , , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5383532/ https://ncbi.nlm.nih.gov/pubmed/27869160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.405 |
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